Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels.

Genes and immunity - 1 Dec 2007

Akkad D A, Arning L, Ibrahim S M, Epplen J T

Abstract excerpt

The interleukin 4 promoter polymorphism -589 C/T (rs2243250) was genotyped in 869 multiple sclerosis (MS) patients and 595 healthy blood donors. Sex-specific MS association was evident whereas two flanking polymorphisms showed insignificant P values. In dual luciferase assays of cultured Jurkat cells the cloned promoter comprising the -589 T allele leads to higher expression as compared to the respective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Interleukin-4

Share to Luciferases

Share to Multiple Sclerosis

Share to Promoter Regions, Genetic

Share to Sex Factors

Source

Identifiers

PMID: 17855802
DOI: 10.1038/sj.gene.6364429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels.PMID 17855802Read ↗

CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms.Semantic proximity Read ↗

CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis.Semantic proximity Read ↗

Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation.Semantic proximity Read ↗

Role of interleukin 4 in Spanish multiple sclerosis patients.Semantic proximity Read ↗

The association of IL-18 gene promoter polymorphisms and the levels of serum IL-18 on the risk of multiple sclerosis.Semantic proximity Read ↗

Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118-kb interval around interferon-gamma (IFNG) that is involved in male versus female differential susceptibility.Semantic proximity Read ↗

The CTLA-4 gene is associated with multiple sclerosis.Semantic proximity Read ↗

Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis.Semantic proximity Read ↗

Interleukin-10 (IL10) promoter polymorphisms and multiple sclerosis.Semantic proximity Read ↗

Gender-specific association between -1082 IL-10 promoter polymorphism and longevity.Semantic proximity Read ↗

Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression.Semantic proximity Read ↗

Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.