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Article

A mutation that uncouples allosteric regulation of carbamyl phosphate synthetase in Drosophila.

Journal of molecular biology - 26 Mar 1999

Simmons A J, Rawls J M, Piskur J, Davidson J N

Abstract excerpt

In animals, UTP feedback inhibition of carbamyl phosphate synthetase II (CPSase) controls pyrimidine biosynthesis. Suppressor of black (Su(b) or rSu(b)) mutants of Drosophila melanogaster have elevated pyrimidine pools, and this mutation has been mapped to the rudimentary locus. We report that rSu(b) is a missense mutation resulting in a glutamate to lysine substitution within the second ATP binding site (i.e....

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PMID: 10080891
DOI: 10.1006/jmbi.1999.2618

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CAD

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