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Article

Integrated allosteric regulation in the S. cerevisiae carbamylphosphate synthetase - aspartate transcarbamylase multifunctional protein.

BMC biochemistry - 5 May 2004

Serre Valérie, Penverne Bernadette, Souciet Jean-Luc, Potier Serge, Guy Hedeel, Evans David, Vicart Patrick, Hervé Guy

Abstract excerpt

BACKGROUND: The S. cerevisiae carbamylphosphate synthetase - aspartate transcarbamylase multifunctional protein catalyses the first two reactions of the pyrimidine pathway. In this organism, these two reactions are feedback inhibited by the end product UTP. In the present work, the mechanisms of these integrated inhibitions were studied. RESULTS: The results obtained show that the inhibition is competitive in the...

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Identifiers

PMID: 15128434
DOI: 10.1186/1471-2091-5-6
PMCID: PMC434488

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