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Article

Structural basis for L-lysine feedback inhibition of homocitrate synthase.

The Journal of biological chemistry - 2 Apr 2010

Bulfer Stacie L, Scott Erin M, Pillus Lorraine, Trievel Raymond C

Abstract excerpt

The alpha-aminoadipate pathway of lysine biosynthesis is modulated at the transcriptional and biochemical levels by feedback inhibition. The first enzyme in the alpha-aminoadipate pathway, homocitrate synthase (HCS), is the target of the feedback regulation and is strongly inhibited by l-lysine....

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Identifiers

PMID: 20089861
DOI: 10.1074/jbc.M109.094383
PMCID: PMC2856251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20089861-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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