Article
Nucleotide recognition in the ATP-grasp protein carbamoyl phosphate synthetase.
Protein science : a publication of the Protein Society - 1 Feb 2004
Kothe Michael, Powers-Lee Susan G
Abstract excerpt
Synthesis of carbamoyl phosphate by carbamoyl phosphate synthetase (CPS) requires the coordinated utilization of two molecules of ATP per reaction cycle on duplicated nucleotide-binding sites (N and C). To clarify the contributions of sites N and C to the overall reaction, we carried out site-dir...
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