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Article

IL-12 Induces IFN Regulating Factor-1 (IRF-1) Gene Expression in Human NK and T Cells

1 Jun 1999

Abstract excerpt

IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes...

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PMID: 10358173
DOI: 10.4049/jimmunol.162.12.7256

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