Article
Thymic microenvironment and NZB mice: the abnormal thymic microenvironment of New Zealand mice correlates with immunopathology.
Clinical immunology (Orlando, Fla.) - 1 Mar 1999
Takeoka Y, Taguchi N, Kotzin B L, Bennett S, Vyse T J, Boyd R L, Naiki M, Konishi J, Ansari A A, Shultz L D, Gershwin M E
Abstract excerpt
There are distinct microenvironmental abnormalities of thymic architecture in several murine models of SLE defined using immunohistochemistry and a panel of mAb dissected at thymic epithelial markers. To address the issue of the relationship between the thymic microenvironment and autoimmunity, we studied backcross (NZB x NZW) F1 x NZW mice in which 50% of offspring develop nephritis associated with proteinuria...
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