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Article

Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.

Experimental neurology - 1 Feb 1999

Bezard E, Gross C E, Fournier M C, Dovero S, Bloch B, Jaber M

Abstract excerpt

MPTP has been shown to induce parkinsonism both in human and in nonhuman primates. The precise mechanism of dopaminergic cell death induced following MPTP treatment is still subject to intense debate. MPP+, which is the oxidation product of MPTP, is actively transported into presynaptic dopaminergic nerve terminals through the plasma membrane dopamine transporter (DAT). In this study, we used mice lacking the DAT...

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Source

Identifiers

PMID: 10072302
DOI: 10.1006/exnr.1998.6995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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