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Article

Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity.

Neurotoxicity research - 1 Aug 2017

Lu Tao, Kim Paul P, Greig Nigel H, Luo Yu

Abstract excerpt

p53 plays an essential role in the regulation of cell death in dopaminergic (DA) neurons and its activation has been implicated in the neurotoxic effects of methamphetamine (MA). However, how p53 mediates MA neurotoxicity remains largely unknown. In this study, we examined the effect of DA-specific p53 gene deletion in DAT-p53KO mice. Whereas in vivo MA binge exposure reduced locomotor activity in wild-type (WT)...

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Identifiers

PMID: 28342134
DOI: 10.1007/s12640-017-9723-z
PMCID: PMC5553619

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