Article
Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells.
The Journal of biological chemistry - 27 Sept 2002
Wu Qun, Kirschmeier Paul, Hockenberry Tish, Yang Tong-Yuan, Brassard Diana L, Wang Luquan, McClanahan Terri, Black Stuart, Rizzi Giovanni, Musco Mary Lynn, Mirza Asra, Liu Suxing
Abstract excerpt
In this study we used adenovirus vector-mediated transduction of either the p53 gene (rAd-p53) or the p21(WAF1/CIP1) gene (rAd-p21) to mimic both p53-dependent and -independent up-regulation of p21(WAF1/CIP1) within a human ovarian cancer cell line, 2774, and the derivative cell lines, 2774qw1 and 2774qw2. We observed that rAd-p53 can induce apoptosis in both 2774 and 2774qw1 cells but not in 2774qw2 cells....
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