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Article

Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.

Traffic (Copenhagen, Denmark) - 1 Jun 2010

Abella Neus, Brun Sonia, Calvo Maria, Tapia Olga, Weber Jason D, Berciano Maria T, Lafarga Miguel, Bachs Oriol, Agell Neus

Abstract excerpt

p21(cip1) is a protein with a dual function in oncogenesis depending mainly on its intracellular localization: tumor suppressor in the nucleus and oncogenic in the cytoplasm. After DNA damage, p21(cip1) increases and accumulates in the nucleus to ensure cell cycle arrest. We show here that the nuclear accumulation of p21(cip1) is not only a consequence of its increased levels but to a DNA damage cellular...

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Identifiers

PMID: 20331843
DOI: 10.1111/j.1600-0854.2010.01063.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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