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Article

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube.

The EMBO journal - 1 Mar 1999

Herrera E, Samper E, Blasco M A

Abstract excerpt

Mice genetically deficient for the telomerase RNA (mTR) can be propagated for only a limited number of generations. In particular, mTR-/- mice of a mixed C57BL6/129Sv genetic background are infertile at the sixth generation and show serious hematopoietic defects. Here, we show that a percentage o...

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Identifiers

PMID: 10064584
DOI: 10.1093/emboj/18.5.1172
PMCID: PMC1171208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10064584-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube.PMID 10064584Read ↗

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Telomere length is reset during early mammalian embryogenesisSemantic proximity Read ↗

Telomere length is inherited with resetting of the telomere set-point.Semantic proximity Read ↗

An Essential Role for Functional Telomeres in Mouse Germ Cells during Fertilization and Early DevelopmentSemantic proximity Read ↗

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.Semantic proximity Read ↗

Haploinsufficiency of mTR results in defects in telomere elongation.Semantic proximity Read ↗

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNASemantic proximity Read ↗

Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development.Semantic proximity Read ↗

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