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Telomerase Is Required for Zebrafish Lifespan

17 Jan 2013

Abstract excerpt

Telomerase activity is restricted in humans. Consequentially, telomeres shorten in most cells throughout our lives. Telomere dysfunction in vertebrates has been primarily studied in inbred mice strains with very long telomeres that fail to deplete telomeric repeats during their lifetime. It is, therefore, unclear how telomere shortening regulates tissue homeostasis in vertebrates with naturally short telomeres....

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PMID: 23349637
DOI: 10.1371/journal.pgen.1003214

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