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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1 Oct 1997

Abstract excerpt

To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six generations analyzed. Telomerase-deficient cells could be immortalized in culture, transformed by viral oncogenes, and generated tumors in nude mice following transformation. Telomeres were shown to...

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PMID: 9335332
DOI: 10.1016/s0092-8674(01)80006-4

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