Article
Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns.
Genome research - 1 Jul 2001
Mohlke K L, Lange E M, Valle T T, Ghosh S, Magnuson V L, Silander K, Watanabe R M, Chines P S, Bergman R N, Tuomilehto J, Collins F S, Boehnke M
Abstract excerpt
Linkage disequilibrium (LD) is a proven tool for evaluating population structure and localizing genes for monogenic disorders. LD-based methods may also help localize genes for complex traits. We evaluated marker-marker LD using 43 microsatellite markers spanning chromosome 20 with an average density of 2.3 cM. We studied 837 individuals affected with type 2 diabetes and 386 mostly unaffected spouse controls. A...
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