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Article

Bone metastasis in prostate cancer: Recurring mitochondrial DNA mutation reveals selective pressure exerted by the bone microenvironment.

Bone - 1 Sept 2015

Arnold Rebecca S, Fedewa Stacey A, Goodman Michael, Osunkoya Adeboye O, Kissick Haydn T, Morrissey Colm, True Lawrence D, Petros John A

Abstract excerpt

BACKGROUND: Cancer progression and metastasis occur such that cells with acquired mutations enhancing growth and survival (or inhibiting cell death) increase in number, a concept that has been recognized as analogous to Darwinian evolution of species since Peter C. Nowell's description in 1976. Selective forces include those intrinsic to the host (including metastatic site) as well as those resulting from...

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Identifiers

PMID: 25952970
DOI: 10.1016/j.bone.2015.04.046
PMCID: PMC4466124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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