Genotype-Guided Hydralazine Therapy

doi:10.1159/000510433

Article

Genotype-Guided Hydralazine Therapy

1 Jan 2020

Abstract excerpt

BACKGROUND: Despite its approval in 1953, hydralazine hydrochloride continues to be used in the management of resistant hypertension, a condition frequently managed by nephrologists and other clinicians. Hydralazine hydrochloride undergoes metabolism by the N-acetyltransferase 2 (NAT2) enzyme. NAT2 is highly polymorphic as approximately 50% of the general population are slow acetylators. In this review, we first...

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