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Article

Interaction of the new histamine H2-receptor antagonist pibutidine hydrochloride with canine cloned H2-receptor expressed cells.

Arzneimittel-Forschung - 1 Jan 1999

Kaku S, Isobe Y, Kiuchi Y, Tanaka M, Muramatsu M, Higuchi S

Abstract excerpt

The effect of a new histamine H2-receptor antagonist, pibutidine hydrochloride ((Z)-3-amino-4-{4-{4-[(piperidinomethyl)pyrid-2-yl]oxy} but-2-enylamino}cyclobut-3-ene-1,2-dione monohydrochloride, CAS 126463-66-9, IT-066 displaced the binding of [3H]tiotidine to cells transfected with the wild-type H2-receptor in a concentration-dependent manner. Compared with the 50% inhibitory concentration values (IC50) among...

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PMID: 10028383
DOI: 10.1055/s-0031-1300362

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