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Article

Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation.

FEBS letters - 27 Aug 2004

Horio Shuhei, Kato Toshiyuki, Ogawa Maki, Fujimoto Katsumi, Fukui Hiroyuki

Abstract excerpt

Human histamine H1 receptor (H1R) contains five possible phosphorylation residues (Thr140, Thr142, Ser396, Ser398 and Thr478) and the substitution of all these five residues to alanine completely impairs agonist-induced receptor downregulation. In the present study, to determine which residue(s)...

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Identifiers

PMID: 15328002
DOI: 10.1016/j.febslet.2004.07.072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15328002-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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