Article
Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor.
Molecular pharmacology - 1 Sept 1997
Boess F G, Monsma F J, Meyer V, Zwingelstein C, Sleight A J
Abstract excerpt
We examined the ligand-binding site of the 5-hydroxytryptamine6 (5-HT6) receptor using site-directed mutagenesis. Interactions with residues in two characteristic positions of trans-membrane region V are important for ligand binding in several bioamine receptors. In the 5-HT6 receptor, one of the...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cells, Cultured
- Cloning, Molecular
- Cricetinae
- Dogs
- Drug Interactions
- Ergolines
- Guinea Pigs
- Humans
- Kidney
- Ligands
- Lysergic Acid Diethylamide
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Rats