Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells.

doi:10.1007/BF00168684

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Article

Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Mar 1992

Boddeke H W, Fargin A, Raymond J R, Schoeffter P, Hoyer D

Abstract excerpt

The characteristics of 5-HT1A-recognition sites and receptor-mediated release of intracellular calcium were established in two transfected HeLa cell lines (HA 6 and HA 7) expressing different levels of human 5-HT1A receptors (about 3000 and 500 fmol/mg protein, Fargin et al. 1989; 1991; Raymond e...

Topics

8-Hydroxy-2-(di-n-propylamino)tetralin
Animals
Calcium
Cloning, Molecular
Extracellular Space
Female
Fura-2
Genetic Variation
HeLa Cells
Humans
Kinetics
Male
Receptors, Serotonin
Serotonin Antagonists
Swine
Tetrahydronaphthalenes
Transfection
Tritium

Source

Open in PubMed

Identifiers

PMID: 1535691
DOI: 10.1007/BF00168684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1535691-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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