Article
23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.
Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2005
Pfister Peter, Corti Natascia, Hobbie Sven, Bruell Christian, Zarivach Raz, Yonath Ada, Böttger Erik C
Abstract excerpt
The 23S rRNA A2058G alteration mediates macrolide, lincosamide, and streptogramin B resistance in the bacterial domain and determines the selectivity of macrolide antibiotics for eubacterial ribosomes, as opposed to eukaryotic ribosomes. However, this mutation is associated with a disparate resistance phenotype: It confers high-level resistance to ketolides in mycobacteria but only marginally affects ketolide...
Topics
- Base Sequence
- Binding Sites
- Clarithromycin
- Drug Resistance, Bacterial
- Ketolides
- Macrolides
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mycobacterium smegmatis
- Nucleic Acid Conformation
- Phenotype