Article
Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance.
Journal of molecular biology - 31 May 1996
Dam M, Douthwaite S, Tenson T, Mankin A S
Abstract excerpt
Mutations in domain II of Escherichia coli 23 S rRNA that cause resistance to erythromycin do so in a manner fundamentally different from mutations at the drug binding site in domain V of the 23 S rRNA. The domain II mutations are located in a hairpin structure between nucleotides 1198 and 1247....
Topics
- Base Sequence
- Drug Resistance, Microbial
- Erythromycin
- Escherichia coli
- Models, Genetic
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptides
- Protein Biosynthesis
- RNA, Ribosomal, 23S