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Article

Binding site of the bridged macrolides in the Escherichia coli ribosome.

Antimicrobial agents and chemotherapy - 1 Jan 2005

Xiong Liqun, Korkhin Yakov, Mankin Alexander S

Abstract excerpt

Ketolides represent the latest group of macrolide antibiotics. Tight binding of ketolides to the ribosome appears to correlate with the presence of an extended alkyl-aryl side chain. Recently developed 6,11-bridged bicyclic ketolides extend the spectrum of platforms used to generate new potent macrolides with extended alkyl-aryl side chains. The purpose of the present study was to characterize the site of binding...

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Share to Anti-Bacterial Agents
Share to Binding, Competitive
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythromycin

Share to Macrolides

Share to Microbial Sensitivity Tests

Share to Ribosomes

Share to RNA, Ribosomal, 23S

Source

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Identifiers

PMID: 15616307
DOI: 10.1128/AAC.49.1.281-288.2005
PMCID: PMC538896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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