Article
Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein.
The EMBO journal - 1 Jan 1992
Gullick W J, Bottomley A C, Lofts F J, Doak D G, Mulvey D, Newman R, Crumpton M J, Sternberg M J, Campbell I D
Abstract excerpt
The neu proto-oncogene may be converted into a dominantly transforming oncogene by a single point mutation. Substitution of a valine residue at position 664 in the transmembrane region with glutamic acid activates the tyrosine kinase of the molecule and is associated with increased receptor dimerization. Previously we have proposed a model in which the glutamic acid side chain stabilizes receptor dimerization by...
Topics
- Amino Acid Sequence
- Animals
- ErbB Receptors
- Hydrogen-Ion Concentration
- Magnetic Resonance Spectroscopy
- Membrane Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oncogene Proteins