Article
Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 1999
Davies E, Holloway C D, Ingram M C, Inglis G C, Friel E C, Morrison C, Anderson N H, Fraser R, Connell J M
Abstract excerpt
Significant correlation of body sodium and potassium with blood pressure (BP) may suggest a role for aldosterone in essential hypertension. In patients with this disease, the ratio of plasma renin to plasma aldosterone may be lower than in control subjects and plasma aldosterone levels may be more sensitive to angiotensin II (Ang II) infusion. Because essential hypertension is partly genetic, it is possible that...
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