Article
Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.
The Journal of clinical endocrinology and metabolism - 1 Sept 2002
Lim Pitt O, Macdonald Thomas M, Holloway Christine, Friel Elaine, Anderson Niall H, Dow Eleanor, Jung Roland T, Davies Eleanor, Fraser Robert, Connell John M C
Abstract excerpt
The aldosterone-to-renin ratio (ARR) is a marker of aldosterone activity in hypertension. We examined the relationship of the ARR to the distribution of two biallelic polymorphisms at the CYP11B2 gene locus. One polymorphism affects a putative steroidogenic factor-1 binding site (-344 T/C) in the 5'-regulatory region, whereas the other marker reflects replacement of the intron-2 from CYP11B2 with that from the...
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