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Article

Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.

Journal of hypertension - 1 Jan 2003

Zhu Haidong, Sagnella Giuseppe A, Dong Yanbin, Miller Michelle A, Onipinla Abiodun, Markandu Nirmala D, MacGregor Graham A

Abstract excerpt

BACKGROUND: Genetic variability in the gene for aldosterone synthase--a key enzyme in the production of aldosterone--can affect sodium homeostasis and thereby blood pressure. The possibility of impaired aldosterone production for the development of hypertension is of particular relevance in black Afro-Caribbeans exposed to a high dietary sodium intake. OBJECTIVES: To compare the frequency of three variants...

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Identifiers

PMID: 12544440
DOI: 10.1097/00004872-200301000-00018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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