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Article

CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension.

Clinical biochemistry - 1 Jan 2010

Nejatizadeh Azim, Kumar Rahul, Stobdan Tsering, Goyal A K, Gupta Mohit, Tyagi S, Jain S K, Pasha M A Qadar

Abstract excerpt

OBJECTIVES: Aldosterone synthase produces aldosterone, which regulates electrolytes and thereby blood pressure. Polymorphisms in aldosterone-synthase gene (CYP11B2) may associate with heterogeneous aldosterone production and hypertension. Hence, we investigated -344T/C, Iw/Ic polymorphisms of CYP11B2, plasma renin activity (PRA) and aldosterone concentration (PAC). DESIGN AND METHODS: Consecutive...

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Identifiers

PMID: 19786005
DOI: 10.1016/j.clinbiochem.2009.09.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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