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Article

Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.

Immunity - 1 Jan 1999

Shiloh M U, MacMicking J D, Nicholson S, Brause J E, Potter S, Marino M, Fang F, Dinauer M, Nathan C

Abstract excerpt

The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed massive abscesses containing commensal organisms, mostly enteric bacteria, even when reared under specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10023768
DOI: 10.1016/s1074-7613(00)80004-7

Genes

NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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