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Article

C57BL/6N Mice Are More Resistant to Ehrlich Ascites Tumors Than C57BL/6J Mice: The Role of Macrophage Nitric Oxide.

Medical science monitor basic research - 20 Oct 2015

Kalish Sergey, Lyamina Svetlana, Chausova Svetlana, Kochetova Lada, Malyshev Yuri, Manukhina Eugenia, Malyshev Igor

Abstract excerpt

BACKGROUND Effectiveness of the immune defense formed by the genotype often determines the predisposition to cancer. Nitric oxide (NO) produced by macrophages is an important element in this defense. MATERIAL AND METHODS We hypothesized that genetic characteristics of NO generation systems can predetermine the vulnerability to tumor development. The study was conducted on mice of 2 genetic substrains - C57BL/6J...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26482575
DOI: 10.12659/msmbr.895555
PMCID: PMC4621162

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