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A superoxide-hypersusceptible Salmonella enterica serovar Typhimurium mutant is attenuated but regains virulence in p47(phox-/-) mice.

Infection and immunity - 1 May 2002

van Diepen Angela, van der Straaten Tahar, Holland Steven M, Janssen Riny, van Dissel Jaap T

Abstract excerpt

Salmonella enterica serovar Typhimurium is a gram-negative, facultative intracellular pathogen that predominantly invades mononuclear phagocytes and is able to establish persistent infections. One of the innate defense mechanisms of phagocytic cells is the production of reactive oxygen species, including superoxide. S. enterica serovar Typhimurium has evolved mechanisms to resist such radicals, and these...

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Source

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Identifiers

PMID: 11953403
DOI: 10.1128/IAI.70.5.2614-2621.2002
PMCID: PMC127934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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