Article
Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16.
The Journal of clinical endocrinology and metabolism - 1 Feb 1999
Kjellman M, Roshani L, Teh B T, Kallioniemi O P, Höög A, Gray S, Farnebo L O, Holst M, Bäckdahl M, Larsson C
Abstract excerpt
To identify chromosomal regions that may contain loci for tumor suppressor genes involved in adrenocortical tumor development, a panel of 60 tumors (39 carcinomas and 21 adenomas) were screened for loss of heterozygosity. Although the vast majority of loss of heterozygosity (LOH) were detected in the carcinomas and involved chromosomes 2, 4, 11, and 18, only few were found in the adenomas. Therefore, 2 loci that...
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