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Characterization of factors that underlie transcriptional silencing in C. elegans oocytes

21 Jul 2023

Abstract excerpt

While it has been appreciated for decades that prophase-arrested oocytes are transcriptionally silenced on a global level, the molecular pathways that promote silencing have remained elusive. Previous work in C. elegans has shown that both topoisomerase II (TOP-2) and condensin II collaborate with the H3K9me heterochromatin pathway to silence gene expression in the germline during L1 starvation, and that the...

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PMID: 37478128
DOI: 10.1371/journal.pgen.1010831

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