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Article

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.

The Journal of biological chemistry - 1 Feb 2024

Lu Jiahui, Ge Peng, Sawaya Michael R, Hughes Michael P, Boyer David R, Cao Qin, Abskharon Romany, Cascio Duilio, Tayeb-Fligelman Einav, Eisenberg David S

Abstract excerpt

Heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) is a human ribonucleoprotein that transports RNA to designated locations for translation via its ability to phase separate. Its mutated form, D290V, is implicated in multisystem proteinopathy known to afflict two families, mainly with myopathy and Paget's disease of bone. Here, we investigate this mutant form of hnRNPA2 by determining cryo-EM structures of the...

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Identifiers

PMID: 38072051
DOI: 10.1016/j.jbc.2023.105531
PMCID: PMC10844680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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