Article

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

2020-09-23

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2, the causative agent of COVID-19<sup>1</sup>, recognizes host cells by attaching its receptor-binding domain (RBD) to the host receptor ACE2<sup>2-7</sup>. Neutralizing antibodies that block RBD-ACE2 interaction have been a major focus for therapeutic development<sup>8-18</sup>. Llama-derived single-domain antibodies (nanobodies, ~15 kDa) offer advantages including ease of pr...

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Literature Corpus work: ffaa6f19-6b67-5d73-99ed-aa86f0fbb7b7
DOI: 10.21203/rs.3.rs-75540/v1

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