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A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2

3 Mar 2021

Abstract excerpt

A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the development of neutralizing antibodies, including llama-derived single-chain nanobodies, to target the receptor-binding motif (RBM) and to block ACE2-RBD binding. Simple and effective strategies to increase potency are desirable for such...

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PMID: 33657135
DOI: 10.1371/journal.ppat.1009328

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