Article

Validation of novel <i>Mycobacterium tuberculosis</i> isoniazid resistance mutations not detectable by common molecular tests

2018-05-15

Abstract excerpt

Resistance to the first-line anti-tuberculosis (TB) drug, isoniazid (INH), is widespread, and the mechanism of resistance is unknown in approximately 15% of INH-resistant (INH-R) strains. To improve molecular detection of INH-R TB, we used whole genome sequencing (WGS) to analyze 52 phenotypically INH-R Mycobacterium tuberculosis complex (MTBC) clinical isolates that lacked the common katG S315T or inhA promote...

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Literature Corpus work: ffa99951-0442-53b4-abd8-5fed252c41de
DOI: 10.1101/322750

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