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Neuronal Deletion of <i>Tumor Susceptibility Gene 101 </i>(<i>Tsg101</i>) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons

2025-05-02

Abstract excerpt

Endosomal dysfunction is one of the earliest cellular signs in Alzheimer’s disease. Tumor susceptibility gene 101 protein (TSG101) is a component of the Endosomal Sorting Complex Required for Transport (ESCRT)-I, which plays a key role in sorting ubiquitinated cell-surface proteins and lipids onto intraluminal vesicles of multivesicular bodies for trafficking to lysosomes or autophagosomes for degradation, or to t...

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Literature Corpus work
ff95ff87-0615-5f19-be2e-79972471bbad
DOI
10.20944/preprints202505.0055.v1
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Neuronal Deletion of <i>Tumor Susceptibility Gene 101 </i>(<i>Tsg101</i>) Causes Rapid Apoptotic Loss of Hippocampal CA3 NeuronsDOI 10.20944/preprints202505.0055.v1
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