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Alzheimer’s disease-associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor <i>Gbf1</i>

2026-05-22

Abstract excerpt

<h4>SUMMARY</h4> Presenilin 2 (PS2) mutations cause familial Alzheimer’s disease, yet their effects beyond amyloid processing remain poorly understood. Here, we investigated how PS2 deletion and the N141I mutation affect neuronal lipid homeostasis and mitochondrial dynamics in mouse primary neurons. Both PS2 deletion and N141I mutation reduced neuronal lipid content. However, exogenous lipid supplementation rescu...

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Literature Corpus work
a8919d30-9cbb-51d6-9dea-7906758199a7
DOI
10.64898/2026.05.20.726466
Open publication

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Alzheimer’s disease-associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor <i>Gbf1</i>DOI 10.64898/2026.05.20.726466
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