Article

Pain persists in mice lacking both Substance P and CGRPα signaling

2023-11-17

Abstract excerpt

<h4>Summary</h4> The neuropeptides Substance P and CGRPα have long been thought important for pain sensation. Both peptides and their receptors are expressed at high levels in pain-responsive neurons from the periphery to the brain making them attractive therapeutic targets. However, drugs targeting these pathways individually did not relieve pain in clinical trials. Since Substance P and CGRPα are extensively co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff8e40ea-dc0b-5ee4-b7d5-a0076fc1bfc3
DOI: 10.1101/2023.11.15.567208

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pain persists in mice lacking both Substance P and CGRPα signalingDOI 10.1101/2023.11.15.567208Read

Essential role of Ret for defining non-peptidergic nociceptor phenotypes and functions in the adult mouse.Semantic proximity Read

Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neuronsSemantic proximity Read

NaV1.8/NaV1.9 double deletion mildly affects acute pain responses in miceSemantic proximity Read

Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice.Semantic proximity Read

Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor.Semantic proximity Read

Modulation of morphine analgesia in alphaCGRP mutant mice.Semantic proximity Read

Parabrachial CGRP Neurons Regulate Opioid ReinforcementSemantic proximity Read

Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.Semantic proximity Read

PACAP induces light aversion in mice by an inheritable mechanism independent of CGRPSemantic proximity Read

Nociceptor-restricted cannabinoid receptor 1 contributes to chronic but not acute analgesiaSemantic proximity Read

Conditional <i>Lpar1</i> gene targeting identifies cell types mediating neuropathic painSemantic proximity Read

Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays.Semantic proximity Read