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Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons

2026-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Patients with bowel disease can develop referred somatic pain at a later time with unknown molecular mechanisms. Using experimental mice with colitis induced by intracolonic installation of 2,4,6-Trinitrobenzenesulfonic acid (TNBS), we find an increase in the percentage of hind paw primary afferent neurons expressing Piezo2 or calcitonin gene-related peptide (CGRP), which are attenuated by TrkB....

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Literature Corpus work
b6e76697-b8c1-5b9f-9606-fa2b1f9bf86e
DOI
10.64898/2026.07.25.740685
Open publication

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Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neuronsDOI 10.64898/2026.07.25.740685
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