Article

PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP

2020-08-20

Abstract excerpt

The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nociceptive functions. In this study, we have used light aversion in mice as a surrogate for migraine-like photophobia to compare CGRP and PACAP and ask whether CGRP or PACA...

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Literature Corpus work: 7a835b42-52f4-5895-a87a-fa35072f782f
DOI: 10.1101/2020.08.20.255968

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