Article

Inducing BDNF and mTOR-Mediated Synaptogenesis via Oral Agents: A Hypothetical Prophylaxis for Alzheimer’s Disease

2025-12-09

Abstract excerpt

Ketamine’s ability to lift mood and spur new synapse growth has put glutamate biology at the center of modern neurotherapeutics. Yet the drug’s intravenous route, monitoring requirements, and dissociative effects make it a poor candidate for long-term prevention of Alzheimer’s disease (AD).Here we advance a testable hypothesis: an all-oral “synaptogenic stack” could mimic ketamine’s downstream benefits—namely, the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d2f9237-8557-5d74-9f02-c83a465f25e8
DOI: 10.20944/preprints202512.0729.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inducing BDNF and mTOR-Mediated Synaptogenesis via Oral Agents: A Hypothetical Prophylaxis for Alzheimer’s DiseaseDOI 10.20944/preprints202512.0729.v1Read

Clearing the Fog with the Cheung's Regimen: A Case of OTC Glutamatergic Augmentation in a Student with Depression, Somatic Symptoms and Cognitive DysfunctionSemantic proximity Read

Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neuronsSemantic proximity Read

The ketamine metabolite ( <i>2R,6R</i> )-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s diseaseSemantic proximity Read

Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature AnalysisSemantic proximity Read

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug DesignSemantic proximity Read

Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer’s disease mouse modelSemantic proximity Read

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic ConsiderationsSemantic proximity Read

Time-Dependent Effects of Rapid-Acting Antidepressants in iPSC-Derived Neurons from Treatment-Resistant Depression and Healthy VolunteersSemantic proximity Read

KDS2010, a newly developed reversible MAO-B inhibitor, as an effective therapeutic candidate for Parkinson’s diseaseSemantic proximity Read

A cholesterol-coupled N-acetyl-aspartyl-glutamate metabolic network facilitates the neuroprotective impact of estradiol in neuronsSemantic proximity Read

Molecular Mechanistic Insights of Pancharavinda Choornam in Cognitive Enhancement and Comorbidity Management in Neurodegenerative DiseaseSemantic proximity Read