Article

Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor-and stem-like cell expansion in the context of <i>ESR1</i> mutation

2025-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Endocrine therapy resistance remains a major challenge in the treatment of advanced estrogen receptor positive (ER+) breast cancer. This can be driven by acquired mutations in the estrogen receptor gene ( ESR1 ), such as Y537S or D538G, that primarily emerge in patients with prior aromatase inhibitor therapy and results in constitutive estrogen-independent ER activity. Progesterone receptors (P...

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Literature Corpus work: 74270c24-c1c0-5df4-a759-9038a6783fc2
DOI: 10.1101/2025.11.20.689560

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