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Article

CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.

Stem cell reports - 8 Apr 2014

Spike Benjamin T, Kelber Jonathan A, Booker Evan, Kalathur Madhuri, Rodewald Rose, Lipianskaya Julia, La Justin, He Marielle, Wright Tracy, Klemke Richard, Wahl Geoffrey M, Gray Peter C

Abstract excerpt

Little is known about the extracellular signaling factors that govern mammary stem cell behavior. Here, we identify CRIPTO and its cell-surface receptor GRP78 as regulators of stem cell behavior in isolated fetal and adult mammary epithelial cells. We develop a CRIPTO antagonist that promotes dif...

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Source

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Identifiers

PMID: 24749068
DOI: 10.1016/j.stemcr.2014.02.010
PMCID: PMC3986630

Genes

CRIPTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24749068-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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