Article

Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics

2022-11-07

Abstract excerpt

Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from non-canonical (nonC) aberrantly translated proteins can be presented on HLA-I by tumor cells. Here, we investigated the immunogenicity of nonC tumor HLA-I ligands (nonC-TL) to better understand their contribution to cancer immunosurveillance and their therapeutic applicability. Using proteogenomics, we identified 517 nonC...

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Literature Corpus work: 70ee95eb-ab30-5e7c-a380-da01bc5d5621
DOI: 10.1101/2022.11.07.514886

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