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Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

23 Oct 2020

Abstract excerpt

Abstract Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated as a tumor-suppressor function for cancer therapy. Recent advance revealed that the sensitivity to ferroptosis is tightly linked to numerous biological processes, including metabolism of amino acid and the biosynthesis of glutathione. Here, by using a high-throughput...

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PMID: 33097833
DOI: 10.1038/s41418-020-00644-4

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