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Article

The Effects of a Curcumin Derivative and Osimertinib on Fatty Acyl Metabolism and Mitochondrial Functions in HCC827 Cells and Tumors.

International journal of molecular sciences - 29 Jul 2023

Hsieh Min-Tsang, Lee Pei-Chih, Chiang Yi-Ting, Lin Hui-Yi, Lee Der-Yen

Abstract excerpt

Drug combination therapy is a key approach in cancer treatments, aiming to improve therapeutic efficacy and overcome drug resistance. Evaluation of intracellular response in cancer cells to drug treatment may disclose the underlying mechanism of drug resistance. In this study, we aimed to investigate the effect of osimertinib, a tyrosine kinase inhibitor (TKI), and a curcumin derivative, 35d, on HCC827 cells and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37569564
DOI: 10.3390/ijms241512190
PMCID: PMC10418893

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