Article

PKLR-modulating compounds show promising effects for the treatment of hepatocellular carcinoma

2024-10-30

Abstract excerpt

<title>Abstract</title> <p>The pyruvate kinase L/R (PKLR) enzyme was associated with the progression of hepatocellular carcinoma (HCC) and metabolic dysfunction-associated fatty liver disease (MAFLD) and identified as a potential drug target. Here, we first demonstrated the anti-HCC effects of recently developed six PKLR-modulating compounds, including SET135, SET156, SET158, SET159, SET171, and SET172 and JNK-IN...

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Literature Corpus work: 0cc7ba52-80e5-5fef-a4a1-766fd82a1b66
DOI: 10.21203/rs.3.rs-5298615/v1

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